INTRINSIC STRUCTURAL DISORDER CONFERS CELLULAR VIABILITY ON ONCOGENIC FUSION PROTEINS.

Chromosomal translocations, which often generate chimeric proteins by fusing segments of two distinct genes, represent the single major genetic aberration leading to cancer.We suggest that the unifying theme charger for dell latitude 3520 of these events is a high level of intrinsic structural disorder, enabling fusion proteins to evade cellular su

Behavioral addictions such as gambling, video games, sex, and shopping share many clinical features with substance use addictions including etiology, course, and neurobiology.Yet, the treatment of behavioral and substance use addictions tends to be separated.However, we argue that a more effective and efficient treatment approach is to conceptualiz